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العنوان
Synthesis Of Some Thienotetrahydroquinoline Derivatives /
المؤلف
Abo El-Hassan, Amr Ahmed Amien.
هيئة الاعداد
باحث / Amr Ahmed Amien Abo El-Hassan
مشرف / Fathy Fahim Abd EL-Latif
مشرف / Adel M. K. EL-Dean
الموضوع
Chemistry, Organic.
تاريخ النشر
2008.
عدد الصفحات
154 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/2008
مكان الإجازة
جامعة المنيا - كلية العلوم - Chemistry Department
الفهرس
Only 14 pages are availabe for public view

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Abstract

A sodium salt of 2-hydroxymethylene cyclohexanon (206) was reacted with cyanothioacetamide in ethanol to afford 2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (207). S-Alkylation of compound (207) was performed easily using -halo carbonyl compounds in ethanol in the presence of sodium acetate to give S-alkylated derivative (208a-g), which cyclized into thienotetrahydroquinoline derivatives (209a-g) when treated with sodium ethoxide in ethanol. Compounds (209a-g) also were obtained from compound (207) directly by refluxing with -halocarbonyl compounds in ethanol in presence of potassium carbonate.