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العنوان
Synthesis of Heterocyclic Compounds Through Cyclization Reactions /
المؤلف
Shaker, Rafat Mohamed.
هيئة الاعداد
باحث / رأفت محمد شاكر حسن
مشرف / فتحى فهيم عبد اللطيف متولى
الموضوع
Heterocyclic compounds. Organic Chemistry.
تاريخ النشر
1989.
عدد الصفحات
105 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
التصنيف العلمي للمقتنيات
تاريخ الإجازة
1/2/1989
مكان الإجازة
جامعة المنيا - كلية العلوم - قسم الكيمياء
الفهرس
Only 14 pages are availabe for public view

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from 183

Abstract

The aim of our work in this part of the thesis is to synthesise some triazino-indoles of biological interest through cyclization reactions of 3-hydrazino- triazino [5,6-b] indole (3) with Nitrous acid (Nano2 / H3Po4) afforded azide (64) wich Could be cyclized with acetic anhydride to give (63b). Also Treatment of (3) with (Nano2 / conc. HC1) gave the Corresponding tetrazole Compound (63a). Refluxing (3) with 1-naphthaldehyde and/or benzal-dehyde in absciute ethanol gave (69a) and (69b) respectively, while refluxing (3) with 1-naphthaldehyde and/or p-nitrobenzaldehde in acetic acid yielded the Corresponding (70 a) and (70 p) respectively. Reaction of (3) eith dicarbony 1 Compound was assumed to involve one or both of the carbony1 reagent condinsations. thus heating eguimolar amounts of (3) and diacety1 in ethanol eave only the Corresponding monohydrazone (71). however in the presence of excess of (3) in galcial acetic acid the Corresopnding dihydrazone (72) was Produced.