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العنوان
Synthesis And Investigations Of Some Potential Biologically Active Novel Thiazoles And Thiazole Condensed Ring Systems =
الناشر
Hesham Tawfik Youssef Fahmy,
المؤلف
Fahmy, Hesham Tawfik Youssef.
هيئة الاعداد
باحث / هشام توفيق يوسف
مشرف / سامية محمد رضا
مشرف / نرجس حبيب
مشرف / السيد احمد بدوى
الموضوع
Pharmaceutical Chemistry.
تاريخ النشر
1993 .
عدد الصفحات
365 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات
تاريخ الإجازة
1/1/1993
مكان الإجازة
جامعة الاسكندريه - كلية الصيدلة - Pharmaceutical Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

It has been well documented that thiazoles, fused thiazoles as well as thiazoles linked to other heterocyclic rings possess a broad spectrum of biological activities, especially antibacterial, antifungal, antiviral and anticancer activities.
On these bases, various series of compounds were synthesized in this thesis (85 new compounds), having a thiazole moiety, to be screened for their antimicrobial, anti-Human Immunodeficiency Virus (HP?) , and anticancer activities.
The Thesis comprises the following main parts.
INTRODUCTION:
This chapter covers a survey of biologically active thiazoles in the field of antibacterial, antifungal, antiviral, antiparazitic and anticancer agents concentrating on the recent researches, and referring to the structure activity relationship whenever possible. it includes the following subdivisions:
I- 4-Thiazolidinone derivatives:
(1) a- 2-aryl-4-thiazolidinones.
b- 2(or 3)-heteryl-4-thiazolidinones.
(2) 2-Thioxo-4-thiazolidinones.
(3) Thiazolidine-2,4-diones.
(4) 2-[rnino-4-thiazolidinones.
II- Compounds containing two thiazole moieties.
III- Thiazolyl benziinidazole derivatives.
IV- Thiazolo[4,5-d]pyrimidine derivatives.