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Abstract This thesis is composed of three parts. In the first part a critical survey of the therapeutically active tranquillizers has been carried out. In the second part four N—aryl substituted phenothiazine derivatives were prepared by Ulmann s reaction namely 1) Phenothiazine N—ni—tolyl. (new) 2) Phenothiazine N—phnyl. 3) Phenothiazine N—O--tolyl. 4) Phenothiazine N—P-.tolyl.II I RI+K2C03 Cu powder Two N—substituted alkyl and alicyclic phenothiazine deriva— tives were also prepared by the action of phenothiazine A-, sodamide and the halogenated derivative of the side chain namely:— 5) Phenothiazine N—(2—hydroxy—3—diethylamino) -propyl. |