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Abstract Aim of the work To investigate the relation between cord blood activin- A level and fetal hypoxia to use activin A as an indicator of perinatal asphyxia. Conclusion It was found that the mean values of activin- A were higher in arterial cord blood than the venous cord blood in asphyxiated group and the control group and this result suggests that the fetus is the main source of activin- A. nRBCs were increased in asphyxiated group. The level of nRBCs per 100 WBCs correlated with acute asphyxia. Further, it can be used as an index of neonatal asphyxia. The correlation found between activin- A and nRBCs suggests that hypoxia is one of the common stimuli for increased erythropoiesis. In conclusion, intrauterine hypoxia is one of the common factors responsible for increasing activin- A levels in fetal circulation. The strong correlation of activin- A with clinical and biochemical signs of fetal and neonatal hypoxia lead us to suggest that activin- A is a possible indicator of intrauterine hypoxia. |