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Abstract Aim of the work To demonstrate the role of respiratory syncytial virus (R.S.V) in the pathogenesis of respiratory tract infections with wheezes in infants and children (3 months-5 years old) in our locality. Summary and conclusion Clinically bronchial asthma and bronchiolitis represent the main bulk of the problem (66%-14%) respectively. R.S.V. has been implicated in most of them. It represents 54.5% of cases of bronchial asthma and all cases (100%) of bronchiolitis. To answer a question about the possible risk of recurrence or chronic respiratory diseases in later life following obstructive airway diseases caused by R.S.V., it is not an easy gob. But cases that give better response with subcutaneous adrenaline injection may be associated with such risk. R.S.V. was isolated by cell culture in 16% of cases while R.S.V. antigen detection by direct immunofluorescence technique was positive in 50% of cases. Ribavirin is a new hope in the field of specific antiviral therapy, being specially indicated in very severe cases complaining prematurity. Congenital heart diseases. Chronic lung disease and immunodeficiency states. In conclusion, the immunofluorescene antibody technique is reliable mean for the rapid diagnosis of R.S.V. infection in infants and children. |