الفهرس 
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Abstract
The aim of this study is to estimate TNF-α, il-8 and IFN-Y Serum levels as well as their values in diagnosing neonatal sepsis.
Conclusions:
In conclusion, TNF-α and IL-8 are elevated in neonates with sepsis and the degree of elevation correlates with the intensity of the disease since the highest levels occurs in neonates with septic shock particularly those who died.
It appears that some cytokines, such as TNF-α, are better correlated with early events (such as septic shock), while others, such as IL-8 is better correlated with late events (such as multiple organ dysfunction or death).
So, the combination of increased serum levels of TNF-α and IL-8 could be considered as sensitive and specific parameters for predicting sepsis, septic shock and their clinical outcomes in newborn infants.
Reduction of the effects of TNF-α and IL-8 by the use of monoclonal antibodies and soluble cytokine receptors might offer the specific treatment of severe sepsis and septic shock. Additional studies have also prompted caution for the general use of TNF-α neutralizing strategies as a treatment modality for bacterial infections.