الفهرس 
Introduction And Aim Of The WorkOnly 14 pages are availabe for public view
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Abstract
The aim of the present prospective study was to evaluate the clinical usefulness of IL-1α and TNF α in sera of newborns with sepsis and children with community acquired pneumonia.
In conclusion IL-1α is decreased in newborns with septicaemia and children with community acquired pneumonia. On the other hand, TNF α is increased in newborns with septicaemia and this is higher in those who had septic shock and died. Also, children with pneumonia had increased levels of serum TNF α. Thus reduction of the effects of TNF α by the use of monoclonal antibodies and soluble cytokine receptors might offer the specific treatment of septic shock of newborns; such intervention has opposite effects during pneumonia. Additional studies have also prompted caution for the general use of TNF α neutralizing strategies as a treatment modality for bacterial infections.