الفهرس 
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Abstract
The aim of the work is to:
Detection of immunoregulatory defect as a pathogenic factor of active rheumatic heart disease through determination of the distribution of mononuclear natural killer cells and T-cell and the correlations between these findings and the clinical and other laboratory results.
In this study, forty five subjects were involved and selected from the inpatient clinics of Kasr EL-Eini hospital and were subdivided into three groups; first group was fifteen active rheumatic heart disease patients (study group) and the other two groups were taken as control (fifteen chronic rheumatic heart disease patients and fifteen apparently healthy individuals) groups. The mentioned groups were submitted to full history, careful clinical examination, laboratory and serological assessment, electrocardiography, radiological plain X ray chest, echocardiography evaluation and finally immunological flowcytometric assessment by specific monoclonal antibodies.
In conclusion, variable immune abnormalities; decreased CD8 cells, deficient NK cells, increased CD4 cells, raised CD4/ CD9 ratio and no statistical change in CD3 pan-T-cells, were obtained in ARHD patients. These findings point to a prominent role of cell mediated immune mechanisms in the pathogenesis of ARHD.