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Abstract Aim of the work The aim of the work is: 1- Evaluate the clinical significant of circulating VEGE in patients with liver cirrhosis. 2- Study its correlation to other laboratory tests (liver function and platelet count). 3- Study its correlation to gastro-oesophageal varices and hepatocellular carcinoma (HCC). Conclusion from the results of this study we conclude the following: 1- There was a strong relation between VEGF level and chronic liver disease (liver cirrhosis, HCC) especially highly correlated with HCC, there was a statistically significant high levels of VEGF in them more than control group. 2- There was no statistically significant correlation between VEGF levels and platelet count in patients with liver cirrhosis. 3- There was strong correlation between VEGF and liver enzymes ALT and AST (degree of hepatic dysfunction). With no correlation with ALP. 4- There was no significant relation between VEGF and the grades of Oesophageal varices in liver cirrhosis. 5- There was no relation between VEGF and degree of splenomegally and ascites in liver cirrhosis patients. 6- There was no significant relation between VEGF and upper GIT bleeding in patients with liver cirrhosis. |