الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
In the present study, it is tried to throw the light on the role of prostanoids, in general, and prostacyclin, in particular, in association with estradiol and progesterone in the pathogenesis of the mysterious subject of dysfunction uterine bleeding. Also, trying to find if there are any local structural changes in the endometrial blood vessels. Aiming to verify by the concept that abnormalities in prostanoid metabolism, whether primary endometrial or secondary to hormonal changes, play a significant part in the etiology of D.U.B., consequently giving a new support for medical treatment of such a problem.
In conclusion:
This study demonstrated that, there is a complicated interaction between sex steroids and endometrial prostscyclin. This is controlled by a well adjusting hypothalamo-pltuitary-ovarian-uterine aixs. Slight disturbance, leads to marked structural changes of the uterine endometrium with occurrence of abnormal uterine bleeding. High level of prostacycline (PG12) in the endometrium of the study group suggesting that, PG12 may be primary responsible about the pathogenesis of DUB as it now considered the main vasodilatory and antiplatelets aggregatory agent in the endometrium in association with secondary disturbance of the plasma level of oestradiol and progesterone.
Rise in the level of plasma oestradiol among the study group associated with increase level of 6 Ket-PGF1 Alpha in the endometrium support the evidence that steroidal is the primary stimulant of prostaglandin synthesis in the endometrium but its rise awe within the normal range replacing the old concept that hyper estrognism, with unopposed of progesterone effect, might be the main cause of DUB.
The low plasma level of progesterone among the study group is associated with high level of 6 Ket-PGF1 Alpha especially in the persistent proliferative endometrium suggesting that progesterone might responsible for local structural changes in the endometrium associated with abnormal uterine bleeding.
The interesting and important changes in the fine ultra structure of endometrial blood vessels making us to not forget this very important local factor in the pathogenesis of DUB which needs further study to allocated its role in DUB.