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Abstract Aim of the work To study the prevalence of arthritis and other rheumatic manifestations clinically and radiologically in outpatients with psoriasis and to correlate skin and nail changes with rheumatic manifestations. Conclusions 1- In psoriasis, clinical and radiological rheumatic manifestations occur in 73% of hospital outpatients. 2- Both psoriasis and psoriatic arthropathy are evenly distributed between females and males. 3- Both psoriasis and psoriatic arthropathy have two peaks of onset, in the third and fifth decades. 4- Most cases of psoriatic arthropathy are preceded by skin and/ or nail disease. In some patients, rheumatic manifestations may precede dermatological manifestations (psoriatic arthropathy in psoriasis), while in a minority, the onset of rheumatic and dermatological manifestations may be simultaneous. 5- Psoriatic arthropathy is positively associated with age, age at onset and disease duration. It is also positively associated with the severity of nail disease, especially in patients with subungual hyperkeratosis. It is however not associated with the type, severity or extent of skin disease. 6- Traditional measures of disease activity such as the morning stiffness, grip strength and ESR may not be useful tools for assessment in psoriatic arthropathy. 7- The functional outcome of psoriatic arthropathy is favorable in most cases. 8- The pattern of psoriatic arthropathy is seldom constant. Most patients evolve into other subsets from the pattern of onset, or have other superimposed rheumatic manifestations during the course of their disease. 9- Peripheral psoriatic arthritis occurs more commonly in patients with chronic long standing psoriasis (on the average 14 days from onset), with a peak age of onset in the fifth decade. 10- Clinically silent radiological involvement is common in psoriatic arthropathy, especially in the big toe, the spine and the DIPs. 11- Spondylitis, with or without sacroiliitis occurs in about two-thirds in patients with psoriatic arthropathy. Silent radiological manifestations may occur in the absence of clinical manifestations. Spondylitis is not associated with the type, severity or extent of skin and nail disease. |