الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
This present work carried out for the study of acute cardiovascular toxic actions the calcium channel blocker ( verapamil) and the cardioselective B.blockers (metoprolol) in guinea pigs. Their effects on electrolytes (Ca++, Na+ and K+) levels in serum and cardiac tissue were also determined. The results indicate that the individnal drug of both groups in a toxic dose induces sinus bradycardia, prolongation of both P.R and Q.T intervals, bundle branch block, complete heart block and ventricular asystole on the surface electrocardiogram and pathologically the lung, liver and kidney showed manifestations of heart failure while there was no pathological changes in the heart.