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Abstract
In the current study, skp2 was immunohistochemically evaluated in 70 cases of diffuse large cell lymphoma (DLCL) and 20 cases of nodal follicular hyperplasia. In DLCL cases, the age of patients ranged between 14 and 85 years with 55 years as a median, and 62.9% of patients were ≤60 years. The
male gender was predominant (67.1%). The primary site of involvement was nodal in 80% of cases. Splenic involvement was present in 25.7% of cases and involvement of more than one extranodal site was seen in 14.3% of cases. Advanced stage (stages III and IV) was noticed in 62.8% of cases. Serum LDH was elevated in 80% of cases, high performance status (PS) ≥ 2 in 75.7% of cases and the revised International Prognostic Index (IPI) score was poor in 58.6% of cases. Total effacement of nodal architecture was identified in 78.6% and 52.9% of cases showed capsular and perinodal fat invasion. The mitotic and apoptotic counts ranged between 2 and 70 with 15 as a median for
mitosis, 0 and 50 with 10 as a median for apoptosis. The studied DLCL cases were classified into; centroblastic (40 cases), immunoblastic (20 cases) and others (10 cases). These other types included 7 cases T-cell rich lymphoma and 3 cases anaplastic large cell lymphoma. Immunoblastic variant was statistically associated with total effacement of nodal architecture (p=0.048) and high apoptotic count (p=0.043) compared to centroblastic variant.