![]() | Only 14 pages are availabe for public view |
Abstract Aim of the work The aim of this work is to study the clinical presentation of bronchial asthma during pregnancy and its relation to cortisol and pregnancy specific β1 glycoprotein (SP1) levels in the maternal blood. Conclusion The circulating concentration of corisol rises throughout pregnany in both asthmatic and non-asthmatic subjects, although its mean value in the former group is significantly higher than those in this latter. Pregnancy specific β1 glycoprotein (SP1) is specifically produced by the placenta, secreted into the maternal blood and its exact biological function is unknown. In the present work, the concentration of SP1 that measured serially in the maternal serum is higher during late pregnancy than early pregnancy in both asthmatic and control group and the mean values were significantly lower in normal pregnant women than in asthmatic pregnant cases. The mechanistic and clinical implications of these findings were discussed. |