الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The aim of this work was to explore the capability of using the adsorption technique onto different carries as means of controlling drug release, prolonging therapeutic activity and alleviating side effects of ketorolac tromethamine. Ketorolac tromethamine (KT), is non-sterodal anti-inflammatory drug. It is a potent analgesic with modest anti-inflammatory activity. The most serious risks associated with the use of ketorolac are gastrointestinal, renal side effects, and elevation of liver function enzymes. Accordingly, KT is a good candidate for the development of controlled release formulations. Some Results: -The drug Loading increasing drug\carrier ratio. - The drug loading was dependent on the carrier type. - Amberlite-CG and activated charcoal had the higher loading percent. - No interaction between the drug and amberlite CG or charcoal in the physical mixtures. - The drug release rate from its resinates was higher in S.G.F. than S.I.F. - All the prepared tablest have good physical and mechanical properties except those prepared using hydroxypropyl methylcellulose. - Drug loading increased with increasing drug\polymer ratio or polymer concentration.