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Abstract
Hemophilia is the most common hereditary bleeding disorder with severe bleeding symptoms. Although the number of hemophiliacs is below 0.1 per thousand in population, the care of these patients consumes a lot of financial expenditures, especially for treatment in appearance of inhibitor. Management of hemophilia is best provided by specialist in a hemophilia treatment centre However, all physicians can meet the patients with hemophilia in urgent situation or with their chronic problems. Hemophilia A is the lack of the Factor VIII protein in the blood that causes the clotting problem that leads to bleeding induced complications, this usually exaggerated with certain factors that lead to more occurrence of bleeding or severe forms as; plasma factor VIII level presence of anti- FVIII inhibitors, age of the patient, activity, immune state types and availability of treatment, socioeconomic state The aim of this work was to find out the risk of occurrence of intracranial hemorrhage among patients suffering from hemophilia with other risk factors related to this complication The present study was conducted on Sixty-nine children known to have hemophilia A. and fifteen normal children as a control They were examined for any clinical bleeding manifestations, CNS insult, consanguinity, bleeding sites, severity and any complications as arthropathies Laboratory evaluation included: Complete blood picture. Hepatitis C and B virus markers by qualitative PCR. Quantitative assay of factor VIII level Assessment of presence of anti-factor VIII inhibitors. CD4% and CD8% expression on lymphocytes by flowcytometry. Evaluation of previously affected joints by X-ray radiography.