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Abstract
The aim of the present investigation was to demonstrate the additive effect of treadmill exercise when combined with AT1 receptor antagonist (losartan) on some hemodynamic and blood parameters in DOCA-salt induced hypertensive rats. Thirty two adult male albino rats, weighing 150-200 gram, were used in this work. The rats were classified into two main groups I- Normotensive group:(8 rats II- Hypertensive group: Classified into three equal subgroups Hypertensive non-treated group (8 rats Hypertensive sedentary AT1 receptor antagonist treated group (8 rats Hypertensive exercised AT1 receptor antagonist treated group (8 rats In each of the previously mentioned groups, MSBP, vascular reactivity of aortic strip to norepinephrine, serum sodium, potassium and lipids were estimated In hypertensive non-treated group, there was significant increase of MSBP, vascular reactivity of isolated thoracic aortic strips to 1 x 10-5 M NE, serum Na+ and fasting serum cholesterol, triglycerides and LDL levels, and a significant decrease in serum K+ and fasting serum HDL levels when compared to the corresponding values in normotensive group In hypertensive sedentary AT1 receptor antagonist treated group, there was a statistical significant decrease of MSBP, vascular reactivity of isolated thoracic aortic strips to 1 x 10-5 M NE and serum Na+ and a significant increase in serum K+ but insignificant effects on fasting serum lipids when compared to the corresponding values in hypertensive non-treated group In hypertensive exercised AT1 receptor antagonist treated group, there was a statistical significant decrease of MSBP, vascular reactivity of isolated thoracic aortic strips to 1 x 10-5 M NE, serum Na+, fasting serum total cholesterol, triglycerides and LDL levels, and a significant increase in serum K+ and fasting serum HDL levels when compared to the corresponding values in hypertensive non-treated group. In addition, there was a statistical significant decrease of MSBP, vascular reactivity of isolated thoracic aortic strips to 1 x 10-5 M NE, fasting serum total cholesterol, triglycerides and LDL levels, and a significant increase in fasting serum HDL levels but insignificant changes in serum Na+ and K+ when compared to the corresponding values in hypertensive sedentary AT1 receptor antagonist treated group.