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Abstract
Virus- related hepatitis is a major health problem worldwide, affecting between 1% and 3% of the people in the developed world, as chronically infected with hepatitis C virus (HCV) and carriage rates in other countries reaching up to 35%.
The estimation of the degree of hepatic fibrosis is important for diagnostic and therapeutic management of patients with chronic liver disease, in particular those associated with viral hepatitis.
At present, liver biopsy remains the only accepted test for staging and grading HCV- related liver disease. However, the procedure is associated with significant patient morbidity and a small but definite risk of death.
There are a variety of ways to interpret liver biopsy. The most common scoring methods include, Metavir and histologic activity index (HAI) also called the Knodell. It is important to remember that the length of the liver specimen and the knowledge of the professional reading the biopsy can influence the interpretation of the report.
The aim of this work is to evaluate the pattern of the Doppler waveform of hepatic veins in healthy volunteers and that in cirrhotic patients and to assess the accuracy of changes in hepatic veins waveform as a diagnostic parameter of liver cirrhosis.
Two groups formed the material of this study, including 30 patients with liver cirrhosis and other 30 non-cirrhotic controls. All patient were subjected to complete history taking, laboratory investigation, histopathological assessment, grey scale US for liver morphology (liver echogenicity, surface irregularity, parenchymal texture, PT diameter, HVs diameter and MHV/PV ratio) and color Dopppler (PV flow volume, HVs waveform).
The statistical analyses were carried out in both groups using P value test; P value for Fisher Exact test (FEp), P value for Monte Carlo test (MCp), All the measurements were .