الفهرس | Only 14 pages are availabe for public view |
Abstract It is concluded that the potentiation of FdUrd efficacy by the concurrent administration of UrdPase inhibitors is evident in the tumors that are deficient or have low dThdPase activity provided that the antitumor efficacy of FdUrd in such tumors is dependent mainly on the inhibition of thymidyllate synthetase. It is also concluded that UrdPase inhibitors can increase the availability of blasma uridine when administered alone or in combination with uridine or TAU. Such capability may be of great importance in the protection from the toxicity of anticancer and anti-AIDS drugs and in treatment of the medical disorders that can be remedied by uridine administration. |