![]() | يوجد فقط 14 صفحة متاحة للعرض العام |
المستخلص Endothelial cells produce the 21 aminoacid peptide endothelin- I, which is formed from its big precursor, big endothelin, via the activity of converting enzyme. The basal production of the peptide is stimulated by epinephrine, angiotenisn Il, aginine vasopressin, transforming growth factor B, thrombin and hypoxia. ET-I is mainly produced by vascular endothelial cells. In vascular smooth muscle, endothelin binds to a specific receptor (ETA, subtype), resulting in an increase in intracellular calcium and vasoconstriction. (Luscher, 1992). Coronary arteries have a high density of binding sites for endothelin-l and endothelin -2 and infusion of these peptides causes intense coronary vasoconstriction (Chester et al., 1989). In this work we studied the changes which occur in plasma endothelin in patients with acute ischemic syndrome. And a trial to find out the relation between plasma endothelin level and left ventricular wall motion score index, cardiac enzymes. S .. ixity individuals were included in this study comprising 20 patients with unstable angina, 20 patients with acute myocardial infarction and 20 age and sex-matched healthy control. All individuals were subjected to full history taking full clinical examination, E.C.G., echocardiographic examination and |