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Abstract
Neonatal cholestasic disorders are a group of hepatobiliary diseases occurring within the first three months of life.
The two most common causes of neonatal cholestasis are biliary atresia (BA) and idiopathic neonatal hepatitis (INH), occurring for up to 50% to 70% of cases.
The clinical presentation of BA and INH is almost similar and the differential diagnosis is sometimes very difficult specially in early months of life.
The accurate diagnostic test for differentiating BA and INH is percutaneous liver biopsy, if an adequate size is obtained and if examined by experienced pathologists.
The aim of this study was to determine the role of quantitative analysis of ductus proliferation, proliferative activity, Kupffer cell proliferation and angiogenesis in the differential diagnosis of BA and INH.
Therefore, we used CK7, Ki67, vimentin and CD34 immunostaining.
This study was based on sixty liver biopsies from patients with BA (30 cases) and INH (30 cases). We detected a female predominance in BA group 21/30 (70%) of cases and male predominance 18/30 (60%) in cases of INH group. All cases were selected in the first three months of life, the mean age was (70 ± 16) and (64 ± 22) days in BA and INH groups respectively.
Comparing the laboratory results between BA group and INH group revealed statistical significance with Gamma Glutamyl Transferase.