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Abstract
Liver cirrhosis is a diffuse process characterized by fibrosis and the conversion of normal liver architecture into structurally abnormal nodules, leading to progressive loss of liver function.
Hepatocellular carcinoma is a malignancy that accounts for 80% to 90% of all liver cancer . It shows high mortality , with one million new cases seen worldwide each year .
CD105 is a 180 kDa transmembrane glycoprotein constitutively phosphorylated with a marked tissue-specificity. CD105 is predominantly expressed on endothelial cell and its promoter is strongly and selectively active in endothelial cells.
In solid neoplasia, CD105 is present on endothelial cells of both peri- and intra-tumoral blood vessels and on tumor stromal components This study aimed to evaluate circulating endoglin (CD105) in the serum of patients with liver cirrhosis and patients with hepatocellular carcinoma.
This study included: 15 patients with cirrhosis with HCV, 15 patients with cirrhosis without HCV, and 30 patients with HCC. The HCC group were sub-classified into 2 subgroups according to AFP level.
In addition 15 apparently healthy individuals were served as a control group.
All groups were subjected to history taking, Complete clinical examination, Liver function tests, prothrombin time and concentration , Hepatitis viral markers including Hepatitis C antibodies(HCV Ab) and hepatitis B surface antigen (HBsAg),Serum alpha fetoprotein (AFP),