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Abstract
Short Tandem Repeat technology is currently the method of choice in all forensic investigations. The selection
of specific STR loci has produced a move toward standardization. Different laboratories in Egypt use either(CODIS) or the European system for DNA profiling without having a concrete idea about the heterogeneity of each STR
locus among the Egyptian population.
The present study was conducted on 420 unrelated individuals (from both sexes and from different parts of Egypt), using seventeen somatic STR loci which were included in two DNA profiling kits; AmpFlSTR Identifiler
(PE Applied Biosystems) and PowerPlex 16 (Promega).
Whole blood and forensic casework samples were included.
Allele frequencies for each allele in each STR locus arising in the DNA typing results were calculated then processed via specialized softwares in order to assess the least number of the
most variant STR loci in the Egyptian population.
The study had put the scientific basis for the ideal DNA profiling system that should be applied in all DNA profiling
laboratories working on Egyptian individuals. This‘‘Egyptian DNA Index System’’ utilizes a group of ten autosomal STR loci besides Amelogenin (as a gender- determining locus) to be
used in all forensic (identity and paternity) applications.