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Abstract
Phosphatidylcholine (PPC) and sodium deoxycholate (DC) are both phospholipids, emulsifiers, and surfactants. Phosphatidylcholine is the most abundant phospholipid component of cell membranes,a precursor to acetylcholine and a constituent of lipoproteins. Deoxycholate is a constituent of bile that solubilizes fat for absorption (Kent et al,2005).
The idea of reducing fat via injections seemed to be taken more seriously after 1999, when Patricia Rittes, a Brazilian dermatologist, published a case series describing injections of PPC into the fat pockets of the lower eyelids in 15 patients (Rittes,2001(a)). Currently, PPC seems to be the primary component of injection lipolysis formulas used (Hexsel et al,2005).
Sodium deoxycholate (DC) which is known as a constituent of bile is a second major ingredient used to keep the PPC soluble and in an injectable form without precipitating out of solution,it is also used alone in injectable lipolysis (Rotunda et al,2004) .
Previous studies suggested that the detergent effect of sodium DC is the major active component of injection lipolysis preparations as it is responsible for cell lysis of human keratinocyte and porcine fat tissue cultures(Rose and Morgan,2006). However, the fact that many injection lipolysis formulations do not include DC suggests that PPC alone has some toxic effect on subcutaneous fat (Hasengschwandtner,2007).
In our study we verified that both treatments have a moderate lipolytic effect without statistical significance between both treatments ( the mean reduction was of 2.31 cm on the PPC-treated side with a percentage of(9.4%) and 2.34 cm on the DC-treated side with a percentage of (9.9%)in skin-fold measurements). The PPC-treated sides had a much easier post-injectable recovery and faster resolution, but DC-treated sides had greater side effects and a much slower resolution.