الفهرس 
AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
During this study ,it was found that the classification of antiprogestins into two types according to their binding to DNA during their action is correct with gel shift assays. In gel shift, human PR bound to RU486 and then extracted and measured for its DNA-binding activity in vitro gel-shift assay is capable of preferential high affinity binding to specific DNA elements (Figure 29). This binding had been observed also with the in vivo assay (fig.20&21&27). Thus , failure of PR to recognize and bind HREs can not adequately explain the antagonist action of RU486. the PR-RU486 complex exhibits the same DNA-binding specificity as the PR-agonist complex (Figure 29). Whether these slight differences in PR-DNA binding properties account for antagonist activity of RU486 is not known.