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Abstract
The goal of this thesis is divided into two parts:
The first part will study:
• Synthesis of different types of zirconium iodomolybdate gels .
• Characterization of the prepared gels.
• Preparation of the active gel, which will be used in 99Mo/ 99mTc chromatographic gel generator.
• Elution performance and quality control of prepared 99Mo/ 99mTc chromatographic gel generator.
The second part will study:
• Radiolabeling of Celecoxib, the selective COX2 inhibitor with 99mTc
• Optimization of Celecoxib labeling conditions.
• Biological distribution of the labeled complex in normal and inflamed mice.
• Quality control of the labeled compound.