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Abstract Aim of the work To assess the homodynamic response of doxacurium chloride and compare it with that of pancuronium bromide in patients undergoing open heart surgery for mitral valve replacement being among the most frequent open heart surgeries in Egypt. Conclusion This study showed that doxacurium chloride has no clinically significant effect on measured or calculated homodynamic variables. Its autonomic margin of safety seems to be wide; in addition, its duration of action is very long. This combination of a long duration of action and absence of circulatory effects makes it very useful in patients with valvular heart disease undergoing prolonged operations. It seems to be the ideal alternative of pancuronium in cardiac surgery. Recommendations We recommend the use of doxacurium chloride instead of pancuronium which causes significant homodynamic response- safely in open heart surgery for patients with mitral valve disease. |