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Abstract SUMMARY Avermectins (AVM) are a new class of structurally related antiparasitic agents isolated from soil organisms. These are a family of macrocyclic lactones, produced by the soil organism Streptomyces avermi tilis which.were discovered in the mid 1970’s as a result of a screening effect for natural products with anthelmintic properties. At present, avermectins are widely used for veterinary purposes, but they are also considered as new and uniquely different products for the control of harmful mites and insects on a variety of crops. In addition, these compounds have other multipurposes use, as an antiparasitic drug and as a potential agent for !control of certain human tropical diseases (e.g. Onchocerciasis, ”river blindness”) Most striking of all, perhaps is the intense scientific activity triggered by the discovery of avermectin compounds. In the fields of chemistry, microbiology, parasitology, entomology, biochemistry, pharmacology and clinical and agricultural sciences, interest in the avermectins has been evolved rapidly. The purpose of this thesis is to elucidate some of the biochemical characteristics of avermectins to shed more light on their biochemical interactions and their mode of action as an~iparasitic and pest control agents. This type of studies will open new avenues . |