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Abstract
from data of this research, it could be noticed that non–invasive markers of liver fibrosis and their combined use will soon become a most useful tool in the clinical management of many forms of chronic liver disease. Additional researches are needed and priority should be given to large scale validation studies of the most promising non invasive markers and of their combinations in the different forms of CLDs accompanied by progressive fibrosis. There is also an urgent need for better assessment and validation of direct fibrogenesis markers that could be implemented in the prognostic evaluation and in dynamic testing of the efficacy of antifibrotic interventions and treatments.