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Abstract
Warts are caused by Human Papilloma Virus (HPV), a double stranded DNA virus. Warts have a variety of clinical manifestations depending on the viral type and site and are usually treated by a wide variety of methods including cryotherapy, surgical excision, podophyllin, bleomycin and various lasers. Each mode of therapy has its own complications and failure rates.
The treatment of patients with multiple, recalcitrant or recurrent verrucae continues to be a formidable task for both primary care physicians and dermatologists. Previous mentioned methods are not always successful and may be associated with adverse events. Even when existing warts are successfully eradicated, patients may develop new warts in other areas.
Immunotherapeutic modalities were introduced to try to overcome the problem of recalcitrant or multiple warts starting from topical immunotherapeutic modalities e.g. DNCB, DCP, SADBE to intralesional injection of candida, mumps, tuberculin or trichophyton.
Candida antigen is a potent immunogen through the production of cell-mediated immunity. Furthermore, candida exposure is ubiquitous although there are rare patients with innate inability to respond to candida antigen. Previous studies reported the regression of warts at sites distant to the originally injected warts.