الفهرس 
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Abstract
Six phenothiazine drugs - promethazine hydrochloride, perazine maleate, chlorpromazine hydrochloride, thioridazine hydrochloride, trifluperazine hydrochloride, and oxomemazine - have been determined in this thesis. The presented thesis falls in five main categories, namely as follows; introduction, analytical review, scope of investigation, experimental, results and discussion. The last one was further classified into five parts, which cover all the suggested procedures.
1. Introduction
It includes information about the investigated compound such as, structural formula, definition, molecular formula, molecular weight, melting point, etc.
2. Analytical review
This category comprises a literature review for the analytical techniques used for the determination of the studied drugs either in pure form or in dosage forms or in biological fluids.
3. Scope of investigation
In this category we summarized the objective of the suggested work in order to develop simple, accurate, sensitive, inexpensive five experimental procedures for determinations of the cited compounds in pure as well as in the available dosage forms.
4. Experimental
In this category we mentioned all the instrument, chemicals, solvents, materials including drugs authentic samples, commercial dosage form available in the local market used throughout the research work. In addition we describe all the procedures required for preparation of different solutions and general procedures suggested for analysis. It also includes all procedures suggested for optimization of variables studied.
5. Results and discussion
In this category a full discussion of all the results obtained are included. It was further divided into five parts:
Part I
The first includes a spectrofluorimetric method based on the condensation of malonic acid and acetic anhydride (MAA) under the catalytic effect of the tertiary amine moiety of the studied phenothiazines to give deeply red color with green florescence. The measurements fluorescence intensity of the product was carried out at λexc. 398 nm, λem. 432 nm.
Part II
The second method which depends on oxidation of certain phenothiazines - promethazine hydrochloride, perazine maleate, trifluperazine hydrochloride - by using cerium (IV) as oxidizing agent and monitoring the relative fluorescence intensity of the produced cerium (III) at λcxe.= 254 nm. and λem.= 355 nm.
Part III
The third method which includes spectrophotometric method for the analysis of the six investigated drugs through formation of charge transfer complexes with 7,7,8,8-tetracyanoquinodimethane (TCNQ), and tetracyanoethylene (TCNE). Under the optimum conditions, the complexes showed green color which has absorption maxima at 842 nm, and yellow color has absorption maxima at 416 nm for TCNQ and TCNE respectively.
Part IV
The fourth method includes another spectrophotometric method for determination of the studied drugs. It is based on oxidation of five phenothiazine drugs using a known excess of cerium (IV) ammonium sulphate and the excess unreacted cerium (IV) was determined with a solution of ρ-aminophenol in perchloric acid and the produced violet colored products were measured at 550 nm. The investigated phenothiazine drugs concentration was determined through decrease in absorbance against reagent blank.
Different variables affecting the suggested procedures at part I - IV were studied and optimized to permit the development of simple, accurate and reproducible procedures for the analysis of the studied phenothiazine drugs.
In all cases and under the specified reaction conditions, calibration curves for the studied drugs were constructed by plotting response (absorbance or RFI) values versus the corresponding drug concentrations.
Sensitivity, accuracy and precision of the proposed procedures were proved according to ICH with suitable statistical treatment of the obtained data.
Part V
In this part, a multivariate analysis procedure using CLS was applied successfully for the analysis of five phenothiazine drugs and their sulphoxides mixture simultaneously. Direct spectrophotometric method together with multivariate statistical treatment is suggested in order to resolve the overlapping between phenothiazine drugs and their sulphoxides in their commercial dosage forms.
In addition, the thesis comprises 185 references, 59 figures, 64 tables and 7 schemes, as well as summary in English and in Arabic.