الفهرس Only 14 pages are availabe for public view
 |  | from | 111 |  |  |
| | | from | 111 | | |
Abstract
The present thesis includes a systematic study on the microdetermination of Furosemide as pharmaceutical drug through formation of Schiff’s bases, using spectrophotometric determination. It comprises three chapters: Chapter I includes an introduction and a literature survey on the methods of determination of Furosemide drug, literature survey on the selected methods are also included Chapter II includes the experimental part, the materials, preparation of various compounds and solutions, instruments used, working procedures and methods of calculation. The recommended procedures depending on formation of Schiff’s bases from reaction of the drug with aromatic aldehyde in acid medium. Chapter III includes the results and discussion: a) Determination of Fu drug through Schiff’s bases formation with different aromatic aldehydes as benzaldehyde (Bz), salicylaldehyde (Sa), 2- and 4-methoxy benzaldehyde (2An) and (4An), vanillin (Va), 2-, 3- and 4-Chlorobenzaldehyde (2Cbz), (3Cbz) and (4Cbz) in methanol. b) Determination Fu drug through formation of Schiff’s bases with different aromatic aldehydes in Chloroform. c) Determination Fu drug through formation Schiff’s bases with different aromatic aldehydes in Benzene. d) Determination Fu drug through formation of Schiff’s bases with different aromatic aldehydes in dichloromethane. e) Studying the effect of different aromatic aldehydes and the effect of different solvents on the formation of Schiff’s bases. f) The proposed methods were applied for determination of the Furosemide drug in some pharmaceutical formulations (Tablets) and (ampoules). g) An Arabic summary is given in addition to the English one and the thesis end with the references which were of great help to the author in his study.