الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
 |  | from | 144 |  |  |
| | | from | 144 | | |
المستخلص
HCC is one of the most common cancers worldwide representing approximately. 4 % of all malignancies. Hepatitis C is a major risk factor and a major health problem in Egypt having the highest seroprevalence in the world affecting app. 10-20% of the population.
The present work focused on studying the role of p21 RAS and IGF II in the pathogenesis of HCV related HCC. 15 cases of HCV hepatitis, 12 cases of HCV related cirrhosis and 15 cases of HCC on top of chronic HCV hepatitis were stained with polyclonal antibodies against p21 ras oncogene and IGF 2.
P 21 RAS expression increased gradually from chronic HCV hepatitis to a peak in the cirrhosis group and then its expression returned to baseline levels in HCC cases . While IGF II expression increased gradually from HCV hepatitis cases to a peak in cirrhosis and remained highly expressed in the HCC cases as well.
A significant positive correlation was observed between p21 RAS expression and the stage in both cirrhosis ( r=0.99, p=o.0001) and HCC cases ( r=0.99, p=0.0001) .
A significant positive correlation was observed between IGF II expression and each of grade ( r=0.409, p=0.01) and stage ( r=0.404, p=0.22) in the cirrhosis group.
Thus it may be deduced that p 21RAS has an important role in the initiation of HCC, however, it has no role in its progression. On the other hand, IGF II may have an important role in both the initiation and progression of HCC occurring on top of HCV hepatitis.
Also, the significant positive correlations observed between each of p21 Ras and IGF II with the stage of the included cases, incriminates fibrosis in the pathogenesis of HCC. Increasing grade also plays a role as evidenced by the positive correlation between IGF II expression and grade of the cases.