الفهرس Only 14 pages are availabe for public view
 |  | from | 80 |  |  |
| | | from | 80 | | |
Abstract
Psoriasis has long been found to be associated with angiogenesis, many factors affect angiogenesis and in turn affect psoriasis extent, these factors may posses either stimulatory or inhibitory effects or combine both effects.
The aim of this study was to study the plasma level of two of these factors which were the vascular endothelial growth factor (VEGF) and the transforming growth factor beta one (TGFβ1) so as to estimate the level of VEGF and TGFβ1 in patients with variable degrees of psoriasis activity determined by psoriasis area and severity index (PASI) and compare it with its levels in normal individuals, and also to assess the correlation between levels of VEGF & TGFβ1 and the degree of psoriatic activity determined by PASI.
Using thirty psoriatic patients and ten age and sex matched healthy volunteers, all subjects (patients & controls) undergone several routine investigations which revealed normal findings as regards the factors that may affect the plasma level of VEGF and TGFβ1. All patients undergone thorough clinical examination to asses psoriasis extent using PASI, then plasma samples were collected from all subjects and examined to determine the level of VEGF concentration using competitive enzyme immunoassay (EIA) and the level of TGFβ1 concentration using enzyme linked immunosorbentassay (ELISA), the patients group was furtherly subdivided into two groups according to PASI score ( gp. I<20 & gp. II>20) .
The results of the study revealed that there was no significant difference between the mean plasma levels of VEGF concentration in patients group in comparison to its levels in normal volunteers, also there was no significant correlation between the plasma level of VEGF and the degree of psoriasis extent measured by PASI in patients group I, while in patient’s group II there was a significant correlation between the plasma level of VEGF and the degree of psoriasis extent measured by PASI.
As for TGFβ1 the results of the study revealed that there was a significant elevation in the mean plasma levels of TGFβ1 concentrations in patients group in comparison to its levels in normal volunteers, but there was no significant correlation between plasma levels of TGFβ1 concentrations and the degree of psoriasis extent measured by PASI in both patient’s groups I & II.
The study discussed the results of many authors who studied the same factors -either in blood or skin- and revealed that many of them reached the same results, but some of them reached different results which could be explained by the different spectra of psoriasis extent between the different studies, also the difference in the individual genetic levels of VEGF & TGFβ1 production among the cases of the different studies, and the difference in the secretion of these factors in response to the disease at the site of psoriatic skin involvement in comparison to its plasma levels.