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Abstract
Background: Prostate cancer(Pca) is considered to be one of most
common cancers in males .Prostatic intraepithelial neoplasia (PIN) and
Atypical adenomatous hyperplasia (AAH), were assumed to be
precursors of prostatic adenocarcinoma. Angiogenesis facilitates
progressive tumour growth by providing adequate oxygenation to the
tumour.Microvessel density (MVD) is considered to be a marker of
the neo-angiogenetic process ,which can be assessed on pathological
slides through the evaluation of immunoreactivity to some endothelial
antigens, eg.CD34.
Materials &methods: The present study done on a total 35 cases of
Pca(25 cases), and AAH(5 cases), (PIN) (5 cases).Also10 cases of
benign prostatic hyperplasia (BPH) used for comparison. MVD was
highlighted by using CD34 immunohistochemical stain. Individual
microvessels were then counted at x200 magnification, MVD was
correlated with age,serum PSA and Gleason score.
Results: Most of(60%) AAH,PIN cases showed MVD(25-50),most
of (68%)Pca cases showed MVD(>50).MVD showed non significant
correlation with age in AAH,PIN &Pca cases ,but showed significant
correlation with serum PSA level in AAH,PIN (P value <0.05) &Pca
cases (P value < 0.01),also MVD showed significant correlation with
Gleason score in Pca cases (P value<0.05).
Conclusion: CD34 immunostaining is a reliable method for counting
the microvesseles in tumors.The microvascular density together with
the Gleason’s grading evaluates successfully the aggressiveness and
prgnosis of prostatic carcinoma.