الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Prostate cancer(Pca) is considered to be one of most common cancers in males .Prostatic intraepithelial neoplasia (PIN) and Atypical adenomatous hyperplasia (AAH), were assumed to be precursors of prostatic adenocarcinoma. Angiogenesis facilitates progressive tumour growth by providing adequate oxygenation to the tumour.Microvessel density (MVD) is considered to be a marker of the neo-angiogenetic process ,which can be assessed on pathological slides through the evaluation of immunoreactivity to some endothelial antigens, eg.CD34. Materials &methods: The present study done on a total 35 cases of Pca(25 cases), and AAH(5 cases), (PIN) (5 cases).Also10 cases of benign prostatic hyperplasia (BPH) used for comparison. MVD was highlighted by using CD34 immunohistochemical stain. Individual microvessels were then counted at x200 magnification, MVD was correlated with age,serum PSA and Gleason score. Results: Most of(60%) AAH,PIN cases showed MVD(25-50),most of (68%)Pca cases showed MVD(>50).MVD showed non significant correlation with age in AAH,PIN &Pca cases ,but showed significant correlation with serum PSA level in AAH,PIN (P value <0.05) &Pca cases (P value < 0.01),also MVD showed significant correlation with Gleason score in Pca cases (P value<0.05). Conclusion: CD34 immunostaining is a reliable method for counting the microvesseles in tumors.The microvascular density together with the Gleason’s grading evaluates successfully the aggressiveness and prgnosis of prostatic carcinoma. |