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Abstract
A total of 160 birds were vaccinated against C.perfringens type ’’A’’ and C” at 12 days of age and boostered after one week, this regime gave a protective immunization against necrotic enteritis (NE).It’s shown that coccidia can be proceed C.perfringens infections. Also using of prebiotics and immunostimulants help in controlling the disease. It’s noted that the toxoid A&C gave a high titer of antibodies. The results also reveal that using of both toxoid and prebiotics may be having a possible interference.