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Abstract
The incidence of cardiovascular disease in renal failure patients on hemodialysis was found to be many folds higher than normal population.
The incidence was found to be higher even with mild renal impairment.
(Tonille, et. al., 2006) .
Renal failure patients are more liable to develop coronary heart disease even if they remain asymptomatic and this was proved when asymptomatic renal failure patients performed coronary angiography for research purpose. (Takayassu et. al., 2005).
In addition to the well known risk factors that predisposes those patients to ischemic heart disease such as diabetes and hypertension new factors are rising to knowledge and those are called Novel cardiovascular risk factors Most important of them is the so called vascular calcification .
Vascular calcification is related to the deposition of excess calcium and
phosphorus in the wall of blood vessels when they exceed certain solubility products. However such process is not simple and many factors control it . (Kettler,et. al. 2005).
Of the main regulators of this process is fetuin A which is glycoprotein
secreted from the liver and acts to inhibit vascular calcification by
different ways. (Reynolds et. al., 2004).
Its level is decreased markedly in renal failure patients and this
predisposes to vascular calcification. (Ketteler et. al., 2003).
Aim of the study: to study fetuin A in renal failure patients and correlate
it with cardiovascular morbidity in the form of ischemic heart disease .
Two groups of renal failure patients were recruited and compared to
third control group with normal renal function.
Group A are renal failure patients on regular hemodialysis with ischemic
heart disease.
Group B are renal failure patients with no history of ischemic heart
diseases
Group C: controls .
Many parameters well be measured in patients and correlated with fetuin
A.