الفهرس | Only 14 pages are availabe for public view |
Abstract The objective of this study was to identify prevalence of dyslipidemia in type1 and type 2 Diabetes .And to assess the D-dimer level in both Diabetic patients. Subjects and methods This study Comprised 90 children and adolescents 26 male and 64female whom had been diagnosed as having one of the types 1 or 2 of diabetes mellitus whom randomly chosen from the regular attendants of the Pediatric Diabetic clinic, in Childern’s Hospital, Ain Shams University. Patients were divided into two groups. Group 1 included 50 children and adolescents with type 1 diabetes. They were 12 males and 38 females. Their chronological age ranged between 5- 18 years with a mean of 13.9±3.9 years. Group 2 included 40 children and adolescents with type2 diabetes. They were 14 males and 26 females. Their chronological age ranged between4- 18 years with a mean of 13.5 ± 2.9 years. All patients were subjected to: History taking, clinical examination with particular emphasis on anthropometric measures, body mass index, assessment of maturity rating according to Tanner’s classification, presence of other autoimmune disorders, local abdominal examination especially for distention or tenderness, cardiovascular reflexes for autonomic neuropathy, full neurological examination to detect evidence of peripheral neuropathy, fundus examination using direct ophthalmoscope for diabetic retinopathy, blood pressure were measured . All patients had done the following laboratory investigations; Random blood sugar (RBS), Glycosylated hemoglobin (HbAlC), Quantitative determination of urinary micro albumin for diabetic nephropathy, Total cholesterol, D-dimer levels in plasma. Results Type II diabetic patients had a significant higher weight and weightSDS (p<0.01), and BMI and BMI SDS (p<0.01) compared to type I diabetic patients. Type I diabetic patients had a significantly longer disease duration compared to type II diabetic patients (p<0.01). In type 1 diabetic patients their were a highly significant relation between D-dimer and diabetic peripheral neuropathy p<0.01) & diabetic retinopathy (p<0.01). In type II diabetic patients their were a significant relation between D-dimer and peripheral neuropathy p<0.05) and no significant difference with retinopathy (p>0.05). C-peptide values were significantly higher among type II diabetics compared to type diabetics (p<0.01). In type 2 diabetics their were a positive significant correlation between cholesterol and BMI (r 0.48) & (p<0.05). In type 1 diabetic patients their were a highly significant correlation between Ddimer levels versus systolic blood pressure (r 0.64 & p<0.01), diastolic blood pressure (r 0.55 & p<0.01). In type 1 diabetics there were asignificant correlation between microalbuminuria and D-dimer and disease duration. On the other hand there were a significant correlation between microalbuminuria and D-dimer and Cholesterol in type 2 diabetics. the ratio of diabetic patients with microalbuminuria in type 2 diabetics were more than in type 1 diabetics with no statistically significant difference in between. Conclusion There were no association between D-dimer and cholesterol in both type1and type 2 diabetes mellitus. But elevated Ddimer levels in both type 1 and type 2 diabetic patients and its association with microvascular complications peripheral neuropathy, retinopathy and nephropathy indicates hypercoagulability. |