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Abstract
The study was performed on 60 neonates classified into three
groups, first group comprised 20 newborns with clinical
manifestation and laboratory finding of neonatal sepsis and with
positive blood culture. Second group comprised 20 neonates with
clinical manifestation of neonatal sepsis and some laboratory
findings but with negative blood culture. A third group of 20 healthy
neonates of the same gestational and postnatal age served as a
control group.
All groups subjected to history taking, careful clinical
examination, laboratory investigation including complete blood
picture, c-reactive protein, blood culture and measurement of
endothelin-1 in plasma using Elisa. We compare the level of
endothelin-1 in plasma in septic neonates who were mechanically
ventilated with the same number of septic neonates who were not
mechanically ventilated to clarify the role of plasma endothelin-1 as
a prognostic marker and to find if it is related to the severity of the
clinical manifestations.
Results:
• Newborns with clinical sepsis and positive blood culture had
significantly higher plasma endothelin-1 (17.10±10.32 pg/ml)
than newborns with clinical sepsis and negative blood culture
(7.88±7.05 pg/ml) (P value = 0.001).• Plasma endothelin-1 correlated with haemoglobin level
(P=0.07), also correlated with platelets (P=0.003), correlated
with band/total leucocytic count (P=0.01).
Conclusion:
Plasma endothelin levels increased during neonatal sepsis
especially with positive blood culture, so can be used a a diagnostic
marker for the neonatal sepsis but can not be used as an indicators
for the severity, or poor outcome.