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Abstract
Carbon tetrachloride (CCl4) is largely used as solvent in chemical industries. CCl4 is also well known for hepatic and renal toxic actions. The in vivo metabolism of carbon tetrachloride to trichloromethyl (CCl3.) and peroxy trichloromethyl (CCl3O2.) radicals has been extensively reported to cause acute liver damage like cirrhosis, steatosis and necrosis. Recently, considerable attention has been focused on dietary and medicinal phytochemicals that inhibit, reverse, or retard diseases caused by oxidative and inflammatory processes. Green tea polyphenols have both antioxidant and anti-inflammatory properties. We have evaluated protective action of green tea extract on CCl4-induced acute hepatictoxicity in male rats. Fifty male Albino rats were divided into five groups, 10 rats each: normal control, green tea extract group, green tea-protected for 15 days and then received an acute dose of CCl4 (i.p.), CCl4-intoxicated and the last 10 rats was the sham group (corn oil). Results demonstrated that protection with green tea ameliorates.