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Abstract
Aging is described as the changes occur in living organisms with the passage of time that lead to functional impairment and ultimately to death. A general decline in various biochemical and physiological functions is noted in most organs during aging resulting in increased susceptibility to age-associated diseases (Srinivasan, 1999). In its original form, the free radical theory of aging proposed that aging is due to the accumulation of unrepaired damage from free radical attack on cellular components. Modern thinking interprets the free radical hypothesis in terms of oxidative stress and the reformulated theory proposes that aging is caused by a shift in the balance between the prooxidative and anti-oxidative processes in the direction of the prooxidative state. It is postulated that aging results from an increase in oxidative damage to lipids, proteins or DNA or alternatively from the effect of the oxidative stress on the regulation of genes that govern processes including differentiation and aging. (Harman, 1992; Beckman and Ames, 1998 and Cadenas and Davies, 2000).