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Abstract
One hundred and fifty male albino rats (l30± 109) were randomly divided into
six groups as following: control group (con). Group (Sel) was given 2ppm of
sodium selenitelliter at drinking water for 3 months. Group (Se2) was given
4ppm of sodium selenite/liter at drinking water for 3 months. Group (Zn l)
received lOOmg of zinc acetate/liter at drinking water for 3 months. Group (Zn2)
received 200mg of zinc acetatelliter at drinking water for 3 months. The sixth
group ( comb) was given 2ppm sodium selenite and lOOmg zinc acetate/l iter in
drinking water for 3 months. Blood samples were collected from 5 animals per
each group at the end of the 1 S\ 2nd and 3rd month of the experiment for
hematological, biochemical and immunological parameters. Tissue samples
were collected at the end of the 1 st, 2nd and 3rd month post treatment. Bone
marrow samples were collected at the end of the 3rd month. Our resulted showed
that high doses of zinc and selenium in addition to combination group were
toxic to rats and caused significant reduction in body weight, macrocytic
hypochromic anemia, leucopenia, and significant undesirable changes in serum
biochemical and immunological parameters. There were multiple pathological
lesions and elevation in frequency on abnormal bone marrow cells together with
increase in total structural aberrations. from the result it could be concluded that
high doses of zinc and selenium were toxic to rats and the addition of zinc to
selenium in combination group resulted in no improvement on the contrary it
increased the toxicity