الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Liver fibrosis is the excessive accumulation of ECM
proteins including collagen that occurs in most types of chronic
liver diseases. Advanced liver fibrosis results in cirrhosis, liver
failure and portal hypertension and often requrres liver
transplantation.
Diagnosis of hepatic fibrosis can be done either invasively
by liver biopsy or none invasively using the biochemical serum
markers of hepatic fibrosis.
Liver biopsy is considered the gold-standard method for the
assessment of liver fibrosis.
Sampling error in liver biopsy can occur, especially when
small biopsies are analyzed. Histologic examination is prone to
intra- and interobserver variation and does not predict disease
progression. Therefore, there is a need for reliable, simple and
noninvasive methods for assessing liver fibrosis.
Clinical investigators have been searching for noninvasive
serum markers of fibrosis. Pathogenesis of liver injury and
fibrogenesis is being used to develop non-invasive tests for
fibrosis that are accurate and replace liver biopsy. These can be
individual markers or a series of markers from which a fibrosis
index can be derived. In either case, these markers tests must have
the following characteristics: They must be reliable, accurate,
reproducible and easy to perform. In addition, they must reflect
total mass of liver collagen and ECM and be able to reflect both
fibrogenesis and fibrosis regression.