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Abstract
Infertility is a common problem world wide, it is either due to male or female factor or combined, male factor represents about 50% of the causes. Male infertility is a multifactorial problem, which might result from impaired spermatogenesis, sperm antibodies, obstruction of the sperm release pathway, sexual problems or hormonal problems. The testicular tissue acts in harmony with hormones of the hypothalamo-pituitary-gonadal axis including FSH, LH and testosterone hormones to endplay a perfect spermatogenesis. FSH plays a crucial role in regulating spermatogenesis through binding to its specific receptor (FSHR) on the Sertoli cells found in the testis, supporting the germinal epithelium. The genetic etiology for infertility is an important cause of disrupted spermatogenesis. Multitudes of SNPs have been identified in the FSHR gene. The SNPs in exon 10 of the FSHR gene such a