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Abstract
Albendazole is a benzimidazole carbamate broad spectrum anthelmintic drug used in veterinary medicine.
The aim of the present work was to study the effect of albendazole on fertility in male rats. Some biochemical as well as histopathological studies were also carried out.
In this work, rats were divided into three groups, each of 15 rats. The first and second groups were given albendazole orally at 30 and 60 mg/kg B. wt respectively. The third group was given saline orally and kept as control.
The obtained results are summarized as follows:
6.1.Effect of albendazole on fertility in male rats:
6.1.1.Effect of albendazole on the index weight of male reproductive organs:
Rats of 1st and 2nd groups treated with 30 and 60 mg/kg B. wt albendazole orally showed significant decrease in index weight of testes after one and two months from onset of drug administration. While there was significant decrease in index weight of epididymes and accessory sex glands after one month from drug administration but returned back to normal level after two months from drug administration.
6.1.2.Effect of albendazole on semen characters:
a. Rats of 1st group (30 mg/kg B. wt orally):
Rats administrated 30 mg albendazole/kg B. wt showed significant decrease on sperm motility after two weeks and one month from drug administration but returned to normal level after two months from drug administration. The sperm cell count of treated rats with albendazole showed significant decrease after two months from drug administration. While there were non significant effect on sperm abnormalities throughout the period of experiment.
b. Rats of 2nd group (60 mg/kg B. wt orally):
There were significant decrease on sperm motility after two weeks and one month from drug administration but returned to normal level after two months from drug administration. The sperm cell count of treated rats with albendazole showed significant decrease after one and two months from drug administration. Sperm abnormalities showed increase after one and two months from onset of drug administration.
6.2.Effect of albendazole on hematological pictures:
At both rat groups, there were insignificant changes in RBCs count, Hb%, WBCs count and PCV% all over the different periods of expermint.
6.3.Effect of albendazole on biochemical findings:
a. Rats of 1st group (30mg/kg B wt orally):
Rats treated with albendazole at 30 mg/kg B. wt orally showed significant increase in serum urea level throughout the period of experiment, while there was significant increase in serum creatinine level after one month from onset of drug administration.
There was significant decrease in globulin level after two weeks from onset of drug administration, while there was significant decrease in total protein level after two weeks and one month from onset of drug administration.
Serum ALT level increased after one and two months from onset of drug administration, while serum AST show no significant changes throughout all periods of experiment.
b. Rats of 2nd group (60 mg/kg B. wt orally):
Rats treated with albendazole at 30 mg/kg B. wt orally showed significant increase in serum urea level throughout the period of experiment, while there was significant increase in serum creatinine level after one month from onset of drug administration.
Rats treated with albendazole showed significant decrease in globulin and total protein level after two weeks from onset of drug administration, while there was significant increase in albumin level after two weeks from onset of drug administration.
Serum ALT level increased after one and two months from onset of drug administration, also serum AST level increased after two months from onset of drug administration.
6.4.Effect of albendazole on the index weight of some internal organs:
Rats treated with albendazole at 30 mg/kg B. wt orally showed significant decrease in index weight of kidneys after one month from drug administration, while at both rat groups, there was significant decrease in index weight of spleen after one and two months from drug administration.
6.5.histopathological effects of albendazole:
a. Rats of 1st group (30 mg/kg B. wt orally):
The testes of the treated rats revealed degenerative and necrobiotic changes of the lining epithelium of some seminiferous tubules and incomplete spermatogenesis.
Some of epididymal tubules revealed moderate nomber of macrophages mixed with spermatozoa in their lumen.
The prostate gland showed congested blood vessels and hyperplasia of the lining epithelial cells
Congestion of central veins, hepatic sinusoids and portal blood vessels of liver with degenerative changes of the hepatocytes in the form of vacuolar and hyDROPic degeneration.
The examined kidneys revealed degenerative changes of the renal convoluted tubules
b. Rats of 2nd group (60 mg/kg B. wt orally):
The histopathological changes of the male genital organs and accessory genital glands revealed congested blood vessels. Some of seminiferous tubules were lined by few layers of spermatogonia and showed absence of spermatogenesis.
Some of epididymal tubules revealed absence of sperm. The prostate gland showed congested blood vessels and hyperplasia of the lining epithelial cells.
Severe congestion with formation of recent thrombi in the central veins and portal blood vessels of liver and Perivascular lymphocytic aggregations around central and portal veins.
Congestion of the renal blood vessels, vacuolar and hyDROPic degeneration of the lining epithelial cells of some renal tubules.
c. Rats of 3rd group (control):
Rats of this group showed no histopathological alterations.