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Abstract
The biological effects of cannabinoids are mediated by specific G protein-coupled cannabinoid (CB) receptors. Two such receptors have been identified: the CB1 receptor, which is highly expressed in the brain but is also present in heart and vascular tissues and the CB2 receptor, expressed primarily by haematopoietic and immune cells .Arachidonoyl ethanolamide or(anandamide) and 2-arachidonoylglycerol, the natural ligands of these receptors, are lipid-like substances called endocannabinoids. The endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, such as mood and anxiety disorders, movement disorders, neuropathic pain, multiple sclerosis, spinal cord injury, cancer, stroke, hypertension, glaucoma atherosclerosis, myocardial infarction, and obesity/metabolic syndrome. However, far less is known about their actions on blood coagulation, and previous few researches show discrapent results. So, the present study is carried out to demonstrate the effects of acute and chronic administration of anandamide on blood coagulation and atherogenic index in both lean and diet induced obese rat models. A total number of 64 healthy adult male albino rats weighting (160-180) gm were used. The animals were bred in the animal house and they had free access to water and kept at room temperature. Rats fed both normal laboratory chew and high fat diet for 7 weeks before injection. Rats were divided into two main groups. Ι -Acute group. (32 animals) subdivided into 4 equal subgroups (each = 8) as the following: Group (1) .This group was injected intraperitoneal (i.p) with a single dose of a vechile consisted of (ethyl alcohol, propylene glycol and normal saline) [1:1:2] 0.02 mg/kg body weight (BW) after feeding on normal laboratory chew diet for 7 weeks. Group (2) .This group was injected (i.p) with a single dose of (anandamide) 0.02 mg/kg BW after feeding on normal laboratory chew diet for 7 weeks. Group (3) High fat diet control group (H.F.C) This group was injected (i.p) with a single dose of the vechile (0.02 mg/kg BW) after feeding on high fat diet for 7 weeks.