الفهرس | Only 14 pages are availabe for public view |
Abstract Endothelin-I (ET-I) is a vasoconstrictive peptide. produced by vascular endothelium and acts in a paracrine manner on adjacent vascular smooth muscle thus continuously regulating the peripheral vascular resistance. There are discordant data on the impact of a hemodialysis session in plasma ET -I level and also contradictory reports on circulating ET- I levels in the presence of elevated blood pressure that frequently accompanies ESRF. The aim of this study is to estimate the plasma level of ET-I in children with chronic Renal Failure (CRF) both on conservative! management and those on hemodialysis and also to compare the effect of ultrafiltration combined with hemodialysis and the effect of isovolumic dialysis on the time course of circulating ET-I in hypertensive and normotensive patients on maintenance hemodialysis. 40 children was enrolled in this study. They were divided into -+ groups. group (A) includes 10 children CRF on conservative management. group (B) includes 10 hypertensive patients with ESRF on regular hemodialysis. group (C) includes 10 normotensive patients with ESRF on regular hemodialysis and group (D) (control group) includes 10 children proved clinically and laboratory to be healthy. All the dialysis patients were on regular hemodialysis 3 times weekly with average duration of dialysis session 3 hours. In this study, the dialysis session was designed into 2 phases: Phase I: The 1 SI 2 hours where ultrafiltration combined with hemodialysis is done. Phase 11: The last hour in which the isovolumic dialysis was done. |