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Abstract
Neutropenia is observed in 40% to 50% of neonates delivered to women
with pregnancy-induced hypertension (Koeing and Christensen, 1989) and
occurs most commonly in very premature infants (Mouzinho et al., 1992).
Although this neutropenia is usually transient and not due to sepsis,
several studies have shown that these neonates may have a higher risk for
~, nosocomial infection in the first few weeks of life (Doron et al., 1994).
Granulocyte Macrophage colony stimulating factor is a hematopoeitic
growth factor for the proliferation, differentiation, survival, and functional
activation of phagocytes [Lieschke and Burgess, (1992), Bailie et al.,
(1994)1·
This work aimed to estimate the cord plasma levels of GM-CSF in
’.... preterm infants and find the relationship between endogenous OM-CSF levels
and absolute neutrophil counts in pregnancy induced hypertension.
This study was carried out in the neonatal unit of pediatric department
together with clinical pathology department in Zagazig University Hospitals
from Jan. 2000 to Oct. 200 I.
The study included 50 pretenn and 10 full term neonates divided into 3
groups as follow:
Group I: 40 pretenn neonates whose gestational ages were below 38 weeks
to mothers suffering from pregnancy induced hypertension.
Group II: 10 full term neonates born to apparently healthy mothers.
Group III: 10 pretenn neonates born to apparently healthy mothers.
Cases and controls were subjected to thorough medical history and
clinical examination. Laboratory investigations have been done including a
104 SummarY, and conclusion
complete blood count, cord plasma level ofGM-CSF by ELISA method and
culture of peripheral blood mononuclear cells to study the granulocyte
macrophage colony forming capacity of the circulating progenitor cells.
Our results showed